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NOEL = No Observed Effect Level; HRIPT = Human Repeat Insult Patch Test; MAX = Human Maximization Test; LOEL = Lowest Observed Effect Level; NA = Not Available 1Data derived from HRIPT or Human Max tests 2Gerberick et al., 2001 2008-02-01 · The RIFM database can function as a focused literature search on fragrance ingredients in preparation for REACH registration. It was established in 1983 and through extensive research, testing and monitoring of literature, RIFM maintains the database as a comprehensive source of physical-chemical, toxicological and eco-toxico-logical data associated with known fragrance and flavor materials. The database is designed to support the FDA's post-marketing safety surveillance program for drug and therapeutic biologic products. The informatic structure of the FAERS database adheres to the international safety reporting guidance issued by the International Conference on Harmonisation (ICH E2B). 2019-08-01 · Each endpoint discussed in this safety assessment includes the relevant data that were available at the time of writing (version number in the top box is indicative of the date of approval based on a 2-digit month/day/year), both in the RIFM database (consisting of publicly available and proprietary data) and through publicly available information sources (e.g., SciFinder and PubMed). Phototoxicity/Photoallergenicity: Not phototoxic/photoallergenic (UV Spectra, RIFM Database) Local Respiratory Toxicity: NOAEC ¼ 10 ppm or 78.65 mg/m3 (0.079 mg/L) (RIFM, 2013b) Environmental Safety Assessment Hazard Assessment: Persistence: Critical Measured Value: 75.4% (OECD 301B) (RIFM, 1993) IFRA STANDARD o,m,p-Tolualdehydes and their mixtures IFRA Standard – o,m,p-Tolualdehydes and their mixtures June 10, 2013 1/3 CAS N°: 529-20-4 620-23-5 RIFM Inc. | RIFM is the international scientific authority for the safe use of fragrance materials. RIFM maintains its Database as the most comprehensive source worldwide.

RIFM reviews upwards of 50 journals a month, conducts literature searches, and regularly collects member company data to keep the RIFM Database as complete as possible. loading loading The RIFM Database RIFM Members Receive Free or Discounted Letters of Access for RIFM Funded Studies After four years of RIFM Membership are completed, LoAs are issued free of charge. The RIFM Database RIFM Fragrance Database Sheet Read more about the scientific and regulatory information that you can find on each ingredient in the RIFM Database. The RIFM Database is the most comprehensive, worldwide source of toxicology data, literature and general information on fragrance and flavor raw materials.

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The association received 700 member company studies into the RIFM Database. RIFM has 70 member companies, and under its agreement with International Organization of the Flavor Industry (IOFI), it will add 100 more studies as well. RIFM has compiled the most comprehensive, worldwide source of toxicology data, literature, and general information on fragrance and flavor raw materials.

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Login to the RIFM Database Fragrance Material Safety Resource Center The RIFM Database RIFM Members Receive Free or Discounted Letters of Access for RIFM Funded Studies RIFM Members Receive Free or Discounted Letters of Access for RIFM Funded Studies All RIFM Members receive either free or discounted Letters of Access (�LoAs�) for RIFM-funded studies that can be used for REACH registration.

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RIFM number: 950 2.

Beginning in 2008, the Research Institute for Fragrance Materials (RIFM) Database will be made available to persons, firms or corporations who are not eligible for membership in RIFM or FEMA but are directly engaged in a business in the fragrance or flavor industry. 2020-04-06 · The RIFM Database is the most comprehensive, worldwide source of toxicology data, literature, and general information on fragrance and flavor raw materials. With upwards of 70,000 references that include more than 135,000 human health and environmental studies, the Database also houses several tools that are crucial to RIFM’s Fragrance Ingredient Safety Assessment and Research programs. Once a material is on the non-supported list, RIFM takes a series of steps to gather data from the primary user or the industry at large.
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Institutionen för kliniska vetenskaper, Malmö

NOEL = No observed effect level; HRIPT = Human Repeat Feb 1, 2002 Animal data.